The EU strategy for endocrine disruptors includes the task of compiling a candidate list of potential endocrine disruptors. The list prioritises the substances that must be evaluated further for endocrine disrupting effects.
The European Commission has prepared a strategy for endocrine disruptors. The short-, medium- and long-term aim of the strategy is to improve the environment and the health of the EU's citizens.
One of the initiatives of the strategy is to compile a list of potential endocrine disruptors. The list is based on the proposals of various organisations and countries for suspected endocrine disruptors.
The proposals were compared and a collective EU list of over 432 candidate substances established, which are to be studied further for endocrine-disrupting properties. In order to prioritise efforts, the substances have been subdivided into a number of categories:
The plan is to convert these lists into a dynamic working list, where substances can be added or removed as more evidence of their endocrine-disrupting properties becomes available.
Category 1 Category 1 contains 194 substances. This does not necessarily mean that there is final proof that the substance is an endocrine disruptor, but there is more or less comprehensive evidence of endocrine-disrupting effects in live animals. The substance should therefore be prioritised for further evaluation of endocrine disrupting properties.
Many of the substances in Category 1 have already been prohibited or are subject to restrictions (this applies to many biocides, for example). Some of the substances are covered by an authorisation scheme under which a risk assessment is performed of the substance’s use in a specific context (such as when used as a biocide, medication, cosmetic product, etc.)
All substances in Category 1 are included in the Danish Environmental Protection Agency's List of Undesirable Substances (LOUS) of 2010 if more than 100 tonnes of the substance are used annually in Denmark, unless they are already prohibited or are covered by an authorisation scheme.
The following table lists the names and CAS numbers of the 194 substances for which evidence of endocrine-disrupting properties has been found in a least one live organism.
Category 1 substances
12789-03-6
57-74-9
Chlordane, – cis- og trans-
143-50-0
Kepone (Chlordecone)
2385-85-5
8001-35-2
Toxaphene (Camphechlor)
50-29-3
DDT (technical) (Clofenotane)
3563-45-9
50471-44-8
12427-38-2
137-42-8
Metam Natrium
137-26-8
12122-67-7
58-89-9
Gamma-HCH (Lindane)
330-55-2
1912-24-9
34256-82-1
15972-60-8
100-42-5
118-74-1
Hexachlorobenzene ( HCB)
85-68-7
Butylbenzylphthalate ( BBP)
117-81-7
DEHP (Di-(2-ethylhexyl) phthalate)
84-74-2
DBP (Di-n-butylphthalate)
80-05-7
Bisphenol A(4,4’-isopropylidendiphenol)
1336-36-3
35065-27-1
PCB 153
32774-16-6
PCB 169
2437-79-8
PCB 47
32598-13-3
PCB 77
53469-21-9
PCB Arochlor 1242
12672-29-6
PCB Arochlor 1248
11097-69-1
PCB Arochlor1254
11096-82-5
PCB Arochlor 1260 (clophen A60)
59536-65-1
PBBs = polybromerede biphenyler (209 congenere)
40321-76-4
1,2,3,7,8 Pentachloro-dibenzodioxin (1,2,3,7,8-PCDD)
1746-01-6
2,3,7,8-Tetrachloro-dibenzo-p-dioxin ( 2,3,7,8-TCDD)
107555-93-1
1,2,3,7,8-Pentabromo-dibenzofuran
No CAS
Tributyltin compounds
688-73-3
Tributyltin hydride
56-35-9
Tributyl Oxide (bis(tributyltin)oxide)
26354-18-7
Stannane, tributylmecrylate (Stannane, tributylmethacrylate)
Methoxyacrylate tributyltin copolymer
4342-30-7
4342-36-3
4782-29-0
36631-23-9
Stannane, tributyl(naphthalenyloxy)- (Tributyltin naphtalate)
85409-17-2
Stannane, tributyl- , mono(naphthenoyloxy)-
24124-25-2
Stannane, tributyl (1-oxo-9,12-octadecadienyl)oxy)-
3090-35-5
Stannane, tributyl((1-oxo-9-octadecenyl)oxy)-
26239-64-5
Stannane, (1R-(1alpha,4abeta,4b alpha,10a alpha))- Tributyl(((1,2,3,4,4a,4b,5,6,10,10a-decahydro-7-isopropyl- 1,4a-dimethyl-1-phenanthryl)carbonyl)oxy)-
1983-10-4
Stannane, tributylfluoro-
2155-70-6
Stannane, tributyl ((2-methyl-1-oxo-2-propenyl)oxy)-
Tributyltincarboxylate
26636-32-8
Tributyltin naphthalate *
2279-76-7
Tri-n-propyltin chloride (TPrT chloride)
900-95-8
Fentin acetate
95-76-1
3,4-Dichloroaniline
108-46-3
61-82-5
Amitrol (Aminotriazol)
1836-75-5
140-66-9
4-tert-octylphenol
25154-52-3
Phenol, nonyl-
1461-25-2
Tetrabutyltin (TTBT)
99-99-0
4-Nitrotoluene
63-25-2
5103-73-1
Cis-Nonachlor
39765-80-5
Trans-Nonachlor
2971-22-4
1,1,1-trichloro-2,2-bis(4-chloro-phenyl)ethane
65148-80-3
3-MeO-o,p'-DDE
43216-70-2
3-OH-o,p'-DDT
65148-81-4
4-MeO-o,p'-DDE
65148-72-3
4-MeO-o,p'-DDT
65148-75-6
5-MeO-o,p'-DDD
65148-82-5
5-MeO-o,p'-DDE
65148-74-5
5-MeO-o,p'-DDT
65148-73-4
5-OH-o,p'-DDT
4329-12-8
m,p'-DDD
65148-83-6
o,p'-DDA-glycinat(N-[(2-chlorophenyl)4-chlorophenyl)acetyl]glycin)
53-19-0
o,p'-DDD
3424-82-6
o,p'-DDE
14835-94-0
o,p'-DDMU
789-02-6
o,p'-DDT
72-54-8
p,p'-DDD
1022-22-6
p,p'-DDMU
72-55-9
p,p'-DDE
32809-16-8
8018-01-7
9006-42-2
Metiram
(Metiram-complex
319-85-7
Beta-HCH
(isomer til gamma-HCH = Lindan)
608-73-1
Hexachlorocyclo-hexane
= HCH mixed (inkluderer gamma-HCH = Lindan)
1689-83-4
2971-36-0
1,1,1-trichloro-2,2-bis(4-Hydroxyphenyl)ethane
(HPTE)
30668-06-5
1,3-Dichloro-2,2-bis(4-methoxy-3- methylphenyl)propane
Bis-OH-Methoxychlor
(1,1,1- trichloro-2,2-bis(4-hydroxyphenyl)ethane (HTPE))
72-43-5
p,p'-Methoxychlor
122-14-5
82657-04-3
Bifenthrin (@Talstar)
91465-08-6
Cyhalothrin, lambda-
52918-63-5
10453-86-8
60168-88-9
1918-02-1
65277-42-1
1087-64-9
86-50-0
Terbutryn
106-93-4
Ethylene Dibromid (1,2-dibromethan or EDB)
12002-48-1
Trichlorobenzene
608-93-5
87-86-5
Pentachlorophenol (PCP)
1806-26-4
4-octylphenol
11081-15-5
4-isooctylphenol
9016-45-9
85535-85-9
Intermediate chain chlorinated paraffins
85535-84-8
Short chain chlorinated paraffins
84-61-7
Dicyclohexyl phthalate (DCHP)
84-66-2
Diethyl phthalate (DEP)
101-53-1
Phenyl-4-hydroxy-phenylmethane (4-Benzylphenol eller p-Benzylphenol)
25036-25-3
2,2'-bis(2-(2,3-epoxypropoxy) phenyl)propane(2,2-BPPP) (isomer til BADGE)
106-89-8
Epichlorohydrin (3-Chloro-1,2-epoxypropane)
35693-92-6
2,4-6-Trichlorobiphenyl
53555-66-1
3,4',5-Trichlorobiphenyl
67651-37-0
3-Hydroxy-2',3',4',5'- tetrachlorobiphenyl
100702-98-5
4,4'-Dihydroxy-2,3,5,6-tetrachlorobiphenyl
13049-13-3
4,4'-Dihydroxy-3,3',5,5'-tetrachlorobiphenyl
67651-34-7
4-Hydroxy-2',3',4',5'-tetrachlorobiphenyl
14962-28-8
4-Hydroxy-2',4',6'-trichlorobiphenyl
53905-33-2
4-Hydroxy-2,2’, 5'-trichlorobiphenyl
111810-41-4
4-Hydroxy-3,3',4',5'-tetrachlorobiphenyl
4400-06-0
4-Hydroxy-3,4’, 5-trichlorobiphenyl
37680-73-2
4-OH-2,2',4',5,5'-pentachlorobiphenyl
54991-93-4
8068-44-8
Clophen A50
Blanding af 2,3,4,5-Tetrachlorobiphenyl (PCB 61), 2,2’, 4,5,5'-Octachlorobiphenyl (PCB 101) og 2,2',3,3',4,4',5,5'-Octachlorobiphenyl (PCB 194)
56558-16-8
PCB 104(2,2',4,6,6'-Penta-chlorobiphenyl)
74472-37-0
PCB 114 (2,3,4,4',5-Penta-chlorobiphenyl)
76842-07-4
PCB 122 (2,3,3',4,5-Penta-chlorobiphenyl)
57465-28-8
PCB 126(3,3',4,4',5-Penta-chlorobiphenyl)
38380-07-3
PCB 128(2,2',3,3',4,4'-Hexachloro-biphenyl)
37680-65-2
PCB 18 (2,2',5-Tri-chlorobiphenyl)
55702-46-0
PCB 21 (2,3,4-Trichloro-biphenyl)
PCB Aroclor 1016
32598-14-4
PCB 105 (2,3,3',4,4' -Penta-chlorobiphenyl)
7012-37-5
PCB 28 (2,4,4'-Tri-chlorobiphenyl)
35693-99-3
PCB 52 (2,2';5,5'-Tetra-chlorobiphenyl)
35065-28-2
PCB 138(2,2',3,4,4',5'- Hexachlorobiphenyl)
35065-29-3
PCB180(2,2',3,4,4',5,5'- Heptachlorobiphenyl)
31508-00-6
PCB 118(2,3',4,4',5-Penta-chlorobiphenyl)
12642-23-8
56614-97-2
3,9-Dihydroxy-benz(a)anthracene (3,9-DBA)
7099-43-6
5,6-Cyclopento-1,2-benzanthracene (3,5-CPBA)
56-49-5
3-Methylcholanthrene (3-MC)
57-97-6
7,12-Dimethyl-1,2-benz(a)anthracene (DMBA)
50-32-8
Benzo[a]pyrene (BAP)
50585-41-6
2,3,7,8-TeBDD (tetrabrominated dibenzodioxin)
118174-38-2
94-82-6
2,4-dichlorophenoxy-butyric acid ( 2,4-DB)
72-33-3
10043-35-3
Boric Acid
104-40-5
Nonylphenol (4-NP)
1113-02-6
1131-60-8
4-Cyclohexylphenol
120-47-8
Ethyl 4-hydroxybenzoate (Ethylparaben)
131-18-0
Di-n-pentylphthalate (DPP)
131-55-5
Benzophenone-2( 2,2’,4,4’ tetra-hydroxybenzophenon)
131-56-6
2,4-Dihydroxybenzophenon (Benzophenone-1)
131-70-4
Mono-n-butylphthalate
13593-03-8
Quinalphos (Chinalphos)
15087-24-8
3-Benzylidene camphor (3-BC)
1582-09-8
1634-04-4
Methyl-tert-butylether (MTBE)
25013-16-5
tert. Butylhydroxyanisol (BHA)
27193-28-8
Phenol, (1,1,3,3-tetramethylbutyl)- (Octylphenol)
33204-76-1
2,6-cis-Diphenylhexamethyl-cyclotetrasiloxane
36861-47-9
3-(4-methyl-benzylidene)camphor
4376-20-9
Mono-2-ethylhexylphthalate (MEHP)
50-18-0
611-99-4
4,4’-Dihydroxy-benzophenone
6164-98-3
Chlordimeform
7400-08-0
p-Coumaric acid (PCA)
77-09-8
3,3’Bis(4-hydroxyphenyl) phthalid (Phenolphthaleine)
77-40-7
2,2-Bis(4-hydroxy-phenyl)-n-butan (Bisphenol B)
92-69-3
4-Hydroxybiphenyl (4-Phenylphenol)
92-88-6
94-13-3
n-Propyl p-hydroxybenzoate (Propylparaben)
94-26-8
n-Butyl p-hydroxybenzoate (Butylparaben)
96-12-8
Dibromochloropropane (DBCP)
96-45-7
99-76-3
Methyl p-hydroxybenzoate (Methylparaben)
99-96-7
p-Hydroxybenzoic acid
____________ * The original report to the EU contained this CAS number, which the Danish Environmental Protection Agency has noted is erroneous. Tributyltin naphthalate is already listed under CAS no. 36631-23-9.